4uhs: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4uhs is ~~ON HOLD until Paper Publication~~

==Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form)==

~~Authors~~: ~~Mechaly~~, A.E., ~~Alzari~~, P.M.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[4uhs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHS OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHS FirstGlance].

~~Description~~: ~~Crystal structure~~ of the ~~receiver domain~~ of ~~CpxR~~ from E. ~~coli~~ ( ~~tetragonal form~~)

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

~~[[Category: Unreleased Structures]]~~

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4uhj|4uhj]], [[4uhk|4uhk]], [[4uht|4uht]]</td></tr>

[[Category: Alzari, P.M.A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhs OCA], [http://pdbe.org/4uhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhs RCSB], [http://www.ebi.ac.uk/pdbsum/4uhs PDBsum]</td></tr>

[[Category: Mechaly, A.E]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CPXR_ECOLI CPXR_ECOLI]] Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).<ref>PMID:23416055</ref> <ref>PMID:7883164</ref> <ref>PMID:9401031</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Alzari, P M.A]]

[[Category: Mechaly, A E]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4uhs is ON HOLD  until Paper Publication
+==Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form)==
+<StructureSection load='4uhs' size='340' side='right' caption='[[4uhs]], [[Resolution|resolution]] 5.00&Aring;' scene=''>
-Authors: Mechaly, A.E., Alzari, P.M.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4uhs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHS FirstGlance]. <br>
-Description: Crystal structure of the receiver domain of CpxR from E. coli ( tetragonal form)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhj|4uhj]], [[4uhk|4uhk]], [[4uht|4uht]]</td></tr>
-[[Category: Alzari, P.M.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhs OCA], [http://pdbe.org/4uhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhs RCSB], [http://www.ebi.ac.uk/pdbsum/4uhs PDBsum]</span></td></tr>
-[[Category: Mechaly, A.E]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CPXR_ECOLI CPXR_ECOLI]] Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).<ref>PMID:23416055</ref> <ref>PMID:7883164</ref> <ref>PMID:9401031</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Alzari, P M.A]]
+[[Category: Mechaly, A E]]
+[[Category: Transcription]]