5h86: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5h86 is ~~ON HOLD until Paper Publication~~

==Human Gcn5 bound to butyryl-CoA==

~~Authors~~: ~~Wolberger~~, C., ~~Ringel~~, A.E.

== Structural highlights ==

<table><tr><td colspan='2'>[[5h86]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H86 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H86 FirstGlance].

~~Description~~: ~~Human Gcn5 bound~~ to ~~butyryl~~-~~CoA~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h86 OCA], [http://pdbe.org/5h86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB], [http://www.ebi.ac.uk/pdbsum/5h86 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Histone acetyltransferase]]

[[Category: Ringel, A E]]

[[Category: Wolberger, C]]

[[Category: ~~Ringel, A.E~~]]

[[Category: Coenzyme some]]

[[Category: Gcn5]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5h86 is ON HOLD  until Paper Publication
+==Human Gcn5 bound to butyryl-CoA==
+<StructureSection load='5h86' size='340' side='right' caption='[[5h86]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
-Authors: Wolberger, C., Ringel, A.E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5h86]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H86 FirstGlance]. <br>
-Description: Human Gcn5 bound to butyryl-CoA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>BCO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h86 OCA], [http://pdbe.org/5h86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB], [http://www.ebi.ac.uk/pdbsum/5h86 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KAT2A_HUMAN KAT2A_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non-histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:17301242</ref> <ref>PMID:19103755</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone acetyltransferase]]
+[[Category: Ringel, A E]]
 [[Category: Wolberger, C]]
-[[Category: Ringel, A.E]]
+[[Category: Coenzyme some]]
+[[Category: Gcn5]]
+[[Category: Transferase]]