4yva: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4yva is ~~ON HOLD~~

==Cathepsin K co-crystallized with actinomycetes extract==

~~Authors~~: ~~Aguda~~, A.H., ~~Nguyen, N~~.T., ~~Bromme~~, D., ~~Brayer, G~~.D.

== Structural highlights ==

<table><tr><td colspan='2'>[[4yva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVA FirstGlance].

~~Description~~: Cathepsin K ~~co-crystallized with actinomycetes extract~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4yv8|4yv8]]</td></tr>

[[Category: Brayer, G.D]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yva OCA], [http://pdbe.org/4yva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yva RCSB], [http://www.ebi.ac.uk/pdbsum/4yva PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>

== Function ==

[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

== References ==

__TOC__

</StructureSection>

[[Category: Cathepsin K]]

[[Category: Aguda, A H]]

[[Category: Brayer, G D]]

[[Category: Bromme, D]]

[[Category: Nguyen, N.T]]

[[Category: Nguyen, N T]]

[[Category: ~~Aguda, A.H~~]]

[[Category: Actinomycete]]

[[Category: Cathepsin k]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4yva is ON HOLD
+==Cathepsin K co-crystallized with actinomycetes extract==
+<StructureSection load='4yva' size='340' side='right' caption='[[4yva]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors: Aguda, A.H., Nguyen, N.T., Bromme, D., Brayer, G.D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yva]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVA FirstGlance]. <br>
-Description: Cathepsin K co-crystallized with actinomycetes extract
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yv8|4yv8]]</td></tr>
-[[Category: Brayer, G.D]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yva OCA], [http://pdbe.org/4yva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yva RCSB], [http://www.ebi.ac.uk/pdbsum/4yva PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cathepsin K]]
+[[Category: Aguda, A H]]
+[[Category: Brayer, G D]]
 [[Category: Bromme, D]]
-[[Category: Nguyen, N.T]]
+[[Category: Nguyen, N T]]
-[[Category: Aguda, A.H]]
+[[Category: Actinomycete]]
+[[Category: Cathepsin k]]
+[[Category: Hydrolase]]