5ic3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ic3 is ~~ON HOLD until Paper Publication~~

==CAL PDZ domain with peptide and inhibitor==

~~Authors~~: ~~Zhao~~, Y., ~~Madden~~, D.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ic3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC3 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC3 FirstGlance].

~~Description~~: ~~CAL PDZ domain with peptide~~ and ~~inhibitor~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PQR:4-[METHYL(NITROSO)AMINO]BENZENE-1,2-DIOL'>PQR</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4jor|4jor]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic3 OCA], [http://pdbe.org/5ic3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic3 ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

== Function ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Madden, D R]]

[[Category: Zhao, Y]]

[[Category: ~~Madden, D.R~~]]

[[Category: Cal pdz]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Peptide binding protein]]

[[Category: Peptide binding protein-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ic3 is ON HOLD  until Paper Publication
+==CAL PDZ domain with peptide and inhibitor==
+<StructureSection load='5ic3' size='340' side='right' caption='[[5ic3]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-Authors: Zhao, Y., Madden, D.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ic3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC3 FirstGlance]. <br>
-Description: CAL PDZ domain with peptide and inhibitor
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQR:4-[METHYL(NITROSO)AMINO]BENZENE-1,2-DIOL'>PQR</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jor|4jor]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic3 OCA], [http://pdbe.org/5ic3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic3 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Madden, D R]]
 [[Category: Zhao, Y]]
-[[Category: Madden, D.R]]
+[[Category: Cal pdz]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Peptide binding protein]]
+[[Category: Peptide binding protein-inhibitor complex]]