1gux

File:1gux.gif

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1gux, resolution 1.85Å (default scene)
Structural annotation: Resources: CATH : 1Guxa00, 1Guxb00 InterPro : Ipr015030, Ipr011028, Ipr013763, Ipr015652, Ipr006670, Ipr002720, Ipr002719 Pfam : PF01858, PF08934, PF01857 SCOP : d1guxa_, d1guxb_ UniProt : P06400
Functional annotation: Cellular component: nucleus PML body chromatin Biological process: regulation of lipid kinase activity negative regulation of cell growth regulation of transcription, DNA-dependent cell cycle checkpoint cell cycle positive regulation of transcription, DNA-dependent negative regulation of transcription from RNA polymerase II promoter transcription chromatin modification negative regulation of protein kinase activity negative regulation of cell cycle M phase androgen receptor signaling pathway G1 phase Molecular function: protein binding transcription coactivator activity DNA binding transcription factor activity kinase binding androgen receptor binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

RB POCKET BOUND TO E7 LXCXE MOTIF

Overview

The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.

About this Structure

1GUX is a Protein complex structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.

Reference

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7., Lee JO, Russo AA, Pavletich NP, Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340 Page seeded by OCA on Fri May 2 18:02:15 2008

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