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| | | #REDIRECT [[5jod]] This PDB entry is obsolete and replaced by 5jod |
| ==Structure of proplasmepsin IV from Plasmodium falciparum==
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| <StructureSection load='4y7h' size='340' side='right' caption='[[4y7h]], [[Resolution|resolution]] 1.62Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[4y7h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y7H FirstGlance]. <br>
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| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7h OCA], [http://pdbe.org/4y7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y7h RCSB], [http://www.ebi.ac.uk/pdbsum/4y7h PDBsum]</span></td></tr>
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| </table>
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
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| Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.,Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289<ref>PMID:9886289</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 4y7h" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Akopjana, I]]
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| [[Category: Jaudzems, K]]
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| [[Category: Recacha, R]]
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| [[Category: Tars, K]]
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| [[Category: Hydrolase]]
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| [[Category: Malaria]]
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