User:Cutter J. Koehler/Sandbox1: Difference between revisions

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== Human metabotropic glutamate receptor 5 transmembrane domain ==
== Human metabotropic glutamate receptor 5 transmembrane domain ==
<StructureSection load='4oo9' size='350' frame='true' side='right' caption='Human metabotropic glutamate receptor 5 transmembrane domain' <'scene='(Ionic_lock)'>
<StructureSection load='4oo9' size='350' frame='true' side='right' caption='Human metabotropic glutamate receptor 5 transmembrane domain' <'scene='(Ionic_lock)'>
This is a default text for your page '''Cutter J. Koehler/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
The Human metabotropic glutamate receptor 5 transmembrane domain is a  
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.


== Structure==
== Structure==
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This is the <scene name='72/726428/Ionic_lock/2'>Ionic Lock in inactive state</scene>.  
This is the <scene name='72/726428/Ionic_lock/2'>Ionic Lock in inactive state</scene>.  


== Function ==
== Function and Pathway ==


== Disease ==
== Disease ==
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== References ==
== References ==
<references/>
<references/>
1.Clemmensen, C., Smajilovic, S., Wellendorph, P., and Brauner-Osborne, H. (2013). “The GPCR, class C, group 6, subtype A (GPCR6A) receptor: from cloning to physiological function.” British Journal of Pharmacology. 171: 1129-41.
2. Dore, Andrew S., Okrasa, Krzysztof, Okrasa., Patel,, Jayesh, C., Serrano-Vega, Maria., Bennett, Kirstie., Cooke, Robert M., Errey, James C., Jazayeri, Ali., Khan, Samir., Tehan, Ben., Weir, Malcolm., Wiggin, Giselle R., Marshall, Fiona H. (2014) “Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.” Nature. 511: 557-62.
3.Feng, Zhiwei, Shifan Ma, Guanxing Hu, and Xiang-Qun Xie.(2015). "Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family." The AAPS Journal AAPS J 17.3 (2015): 737-53.
4Niswender, Colleen M., and P. Jeffrey Conn.(2010). "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease." Annu. Rev. Pharmacol. Toxicol. Annual Review of Pharmacology and Toxicology 50.1: 295-322. Web.
5"Novartis Announces Results of Mavoglurant (mGluR5) (AFQ056) Clinical Trials and the Conclusion of the Long-Term Extension Study" (2014). NFXF. Foward, 24 Apr. Web.
6. Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye W., Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P.J., Stevens, Raymond C. (2014) “Structure of class C GPCR metabotropic glutamate receptor 1 Bound to an Allosteric Modulator.” Science. 344: 58-64.
7. Woodcook, Elizabeth A., Kistler, Peter M., Ju, Yue-Kun. (2009) “Phosphoinositide signalling and cardiac arrhythmias.” European Society of Cardiology. 82: 286-95.
8."4009."(2014). Structure of the Human Class C GPCR Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator Mavoglurant. RCSB PDB, n.d. Web. 22 Feb. 2016
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