1h2p: Difference between revisions
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'''HUMAN CD55 DOMAINS 3 & 4''' | '''HUMAN CD55 DOMAINS 3 & 4''' | ||
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[[Category: Spiller, B.]] | [[Category: Spiller, B.]] | ||
[[Category: Williams, P.]] | [[Category: Williams, P.]] | ||
[[Category: | [[Category: Alternative splicing]] | ||
[[Category: | [[Category: Bacterial receptor]] | ||
[[Category: | [[Category: Complement decay accelerating factor]] | ||
[[Category: | [[Category: Complement pathway]] | ||
[[Category: | [[Category: Enteroviral receptor]] | ||
[[Category: | [[Category: Gpi-anchor]] | ||
[[Category: | [[Category: Ligand for cd97]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:11 2008'' | |||
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Revision as of 15:21, 2 May 2008
HUMAN CD55 DOMAINS 3 & 4
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
About this Structure
1H2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389 Page seeded by OCA on Fri May 2 18:21:11 2008
