Sandbox Reserved 1170: Difference between revisions
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[[Image:4phutopviewlabels.png |200 px|right|thumb|Figure Legend]] | [[Image:4phutopviewlabels.png |200 px|right|thumb|Figure Legend]] | ||
<scene name='72/721542/Top_view_transmembrane_helices/2'>top view of TM helices</scene> | <scene name='72/721542/Top_view_transmembrane_helices/2'>top view of TM helices</scene> | ||
== Structure == | == Structure == | ||
Like most G-protein coupled receptors, hGPR40 contains '' | Like most G-protein coupled receptors, hGPR40 contains <scene name='72/721542/Transmembrane_helices/2'>seven transmembrane helices</scene>. In order obtain a crystallized structure of the protein, four <scene name='72/721541/Stabilizing_mutations/3'>stabilizing mutations</scene> (<scene name='72/721541/L42a/2'>L42A</scene>, <scene name='72/721541/F88a/2'>F88A</scene>, <scene name='72/721541/G103a/2'>G103A</scene>, <scene name='72/721541/Y202f/2'>Y202F</scene>) were made to increase expression levels and thermal stability of the protein.<ref name="Srivastava"/> | ||
=== Binding Sites === | === Binding Sites === | ||
