Sandbox Reserved 1165: Difference between revisions

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===Introduction===

[[Image:Screen_Shot_2016-03-22_at_6.25.34_PM.png|(|):|350 px|right|thumb|<font size="3.0"><div style="text-align: center;">Overall mesh structure of human glucagon class B GPCRs </div></font>]]

<scene name='72/721536/Class_b_receptor/1'>Human glucagon class B G protein-coupled receptors (GPCRs)</scene>, also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family<ref name="Intro">PMID: 24359917</ref> . Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon] which leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and [https://en.wikipedia.org/wiki/Liver extracellular domain] <scene name='72/721536/Ecd/1'>(ECD)</scene> that are of vital importance in glucagon binding. In comparison, class A vs. class B glucagon receptors share less than fifteen percent sequence homology, but both share this 7TM which is a primary area of comparison between the two <ref name="Intro">PMID: 24359917</ref>. The understanding of class A family of GCGRs structure-function [https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme_Catalytic_Mechanism mechanism] has made great progress over the past few years, but understanding of class B has fallen behind.

<scene name='72/721536/Class_b_receptor/1'>Human glucagon class B G protein-coupled receptors (GPCRs)</scene>, also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family<ref name="Intro">PMID: 24359917</ref> . Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon] which leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] <scene name='72/721536/7tm/1'>(7TM)</scene> and [https://en.wikipedia.org/wiki/Liver extracellular domain] <scene name='72/721536/Ecd/1'>(ECD)</scene> that are of vital importance in glucagon binding. In comparison, class A vs. class B glucagon receptors share less than fifteen percent sequence homology, but both share this 7TM which is a primary area of comparison between the two <ref name="Intro">PMID: 24359917</ref>. The understanding of class A family of GCGRs structure-function [https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme_Catalytic_Mechanism mechanism] has made great progress over the past few years, but understanding of class B has fallen behind.

Sandbox Reserved 1165: Difference between revisions

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 ===Introduction===
 [[Image:Screen_Shot_2016-03-22_at_6.25.34_PM.png|(|):|350 px|right|thumb|<font size="3.0"><div style="text-align: center;">Overall mesh structure of human glucagon class B GPCRs </div></font>]]
-<scene name='72/721536/Class_b_receptor/1'>Human glucagon class B G protein-coupled receptors (GPCRs)</scene>, also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family<ref name="Intro">PMID: 24359917</ref> . Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon] which leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and [https://en.wikipedia.org/wiki/Liver extracellular domain] <scene name='72/721536/Ecd/1'>(ECD)</scene> that are of vital importance in glucagon binding. In comparison, class A vs. class B glucagon receptors share less than fifteen percent sequence homology, but both share this 7TM which is a primary area of comparison between the two <ref name="Intro">PMID: 24359917</ref>. The understanding of class A family of GCGRs structure-function [https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme_Catalytic_Mechanism mechanism] has made great progress over the past few years, but understanding of class B has fallen behind.
+<scene name='72/721536/Class_b_receptor/1'>Human glucagon class B G protein-coupled receptors (GPCRs)</scene>, also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family<ref name="Intro">PMID: 24359917</ref> . Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon] which leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] <scene name='72/721536/7tm/1'>(7TM)</scene> and [https://en.wikipedia.org/wiki/Liver extracellular domain] <scene name='72/721536/Ecd/1'>(ECD)</scene> that are of vital importance in glucagon binding. In comparison, class A vs. class B glucagon receptors share less than fifteen percent sequence homology, but both share this 7TM which is a primary area of comparison between the two <ref name="Intro">PMID: 24359917</ref>. The understanding of class A family of GCGRs structure-function [https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme_Catalytic_Mechanism mechanism] has made great progress over the past few years, but understanding of class B has fallen behind.