Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments] (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.
== Structure ==
== Structure ==
Latest revision as of 19:16, 29 March 2016
<math></math>==Human GPR40, also known as Free Fatty Acid Receptor 1 (FFAR1)==
Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side.Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.
