Sandbox Reserved 1172: Difference between revisions
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=== Endocannabinoid Receptor 1 === | === Endocannabinoid Receptor 1 === | ||
LPA1 also is closely related to the [http://www.nature.com/ijo/journal/v30/n1s/full/0803272a.html cannabinoid receptor] [https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_1 CB1]. This close relation gives CB1 the ability to bind to analogs of LPA and vice versa, which opens the possibility of metabolic crosstalk between the two signaling systems. | LPA1 also is closely related to the [http://www.nature.com/ijo/journal/v30/n1s/full/0803272a.html cannabinoid receptor] [https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_1 CB1]. This close relation gives CB1 the ability to bind to analogs of LPA and vice versa, which opens the possibility of metabolic crosstalk between the two signaling systems. This connection is made possible through ligand phosphorylation and dephosphorylation. Specifically, complementary access to the LPA1 binding pocket can be achieved by phosphorylated CB1 ligand analogs, while complementary access to the CB1 binding site required dephosphorylation of LPA1 ligand analogs. | ||
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