Sandbox reserved 1169: Difference between revisions
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<StructureSection load='4GRV2.pdb' size='340' side='right' caption='Neurotensin G-Protein Coupled Receptor' scene='72/721539/Overall_structure/3'> | <StructureSection load='4GRV2.pdb' size='340' side='right' caption='Neurotensin G-Protein Coupled Receptor' scene='72/721539/Overall_structure/3'> | ||
== Introduction == | == Introduction == | ||
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone neurotensin ( | The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone neurotensin (NTS). There are currently around 800 G protein-coupled receptors that have been identified and are thought to be responsible for roughly 80% of signal transduction across the cell membrane.<ref name="Millar">PMID:20019124</ref> These receptors are involved in a vast array of physiological processes within the body that range from interactions with dopamine to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become a major site of drug targets in medicine making a deeper, more in depth understanding of these proteins very important. <ref name="Fang">PMID:23573662</ref> There are currently no NTRS1 structures of the inactive state, so there is no way to determine the conformational changes of the binding pocket caused by the binding of NTS. <ref name="White">PMID:23051748</ref> | ||
== Neurotensin == | == Neurotensin == | ||
<scene name='72/721539/Nts8_13/1'>Neurotensin(NTS)</scene> is a 13-amino acid peptide originally isolated from bovine hypothalamus. It fulfills the role of both a neurotransmitter and a neuromodulator in the nervous system and a hormone in the periphery. NTS is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It is also a paracrine and endocrine modulator in the periphery of the digestive tract and cardiovascular system. Finally, NTS serves as a growth factor for many normal and cancerous cell types.(Neurotensin and | <scene name='72/721539/Nts8_13/1'>Neurotensin(NTS)</scene> is a 13-amino acid peptide originally isolated from bovine hypothalamus. It fulfills the role of both a neurotransmitter and a neuromodulator in the nervous system and a hormone in the periphery. NTS is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It is also a paracrine and endocrine modulator in the periphery of the digestive tract and cardiovascular system. Finally, NTS serves as a growth factor for many normal and cancerous cell types.(Neurotensin and | ||
