Sandbox Reserved 1174: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 11: | Line 11: | ||
Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. Autotaxin was originally linked with metastasis, and this link was later discovered to be mediated through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>. | Extracellularly, LPA is produced from lysophosphatidylcholine by the enzyme autotaxin. Autotaxin was originally linked with metastasis, and this link was later discovered to be mediated through the production of LPA, which signals cell proliferation.<ref name= "Boutin"> DOI: 10.1007/s00018-009-0056-9 </ref> All of LPA’s activities are receptor mediated; the signalling lipid interacts with at least six G-protein coupled receptors LPA<sub>1</sub>-LPA<sub>6</sub>. | ||
== Function == | == Function == | ||
| Line 23: | Line 17: | ||
LPA<sub>1</sub> is part of the larger EDG (endothelial differentiation gene) family which includes the sphingosine 1-phosphate receptors. Compare to S1P… | LPA<sub>1</sub> is part of the larger EDG (endothelial differentiation gene) family which includes the sphingosine 1-phosphate receptors. Compare to S1P… | ||
== Structure == | == Structure == | ||
| Line 35: | Line 27: | ||
The receptor lies in the membrane as shown in Figure 3, and as shown by the <scene name='72/721545/Membrane/1'>fatty acid</scene> bound to it in orange. | The receptor lies in the membrane as shown in Figure 3, and as shown by the <scene name='72/721545/Membrane/1'>fatty acid</scene> bound to it in orange. | ||
[[Image:LPA_in_membrane.fw.png|200px|center|thumb|'''Figure | [[Image:LPA_in_membrane.fw.png|200px|center|thumb|'''Figure 3:''' LPA in membrane]] | ||
=== Structural Stabilization === | === Structural Stabilization === | ||
