Sandbox Reserved 1170: Difference between revisions

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== Background ==

Human G-protein coupled receptor 40 (hGPR40), also known as free fatty acid 1 receptor (FFAR1), is a seven helical transmembrane domain receptor for long-chain free fatty acids that stimulates [[insulin]] secretion.<ref name="Srivastava">PMID:25043059</ref> This [http://www.britannica.com/science/enzyme enzyme] is primarily located in the [https://en.wikipedia.org/wiki/Beta_cell pancreatic β-cells] in the [https://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans], and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments].<ref name="Kebede">PMID:22308370</ref> Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration.<ref name="Ma">PMID:26620255</ref> GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.<ref name="Burant">PMID:23882043</ref>

Human G-protein coupled receptor 40 (hGPR40), also known as free fatty acid 1 receptor (FFAR1), is a seven helical transmembrane domain receptor for long-chain free fatty acids that stimulates [[insulin]] secretion.<ref name="Srivastava">PMID:25043059</ref> Some known fatty acid substrates of hGPR40 include linoleic acid, oleic acid, eicosatrienoic acid, and palmitoleic acid. This [http://www.britannica.com/science/enzyme enzyme] is primarily located in the [https://en.wikipedia.org/wiki/Beta_cell pancreatic β-cells] in the [https://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans], and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments].<ref name="Kebede">PMID:22308370</ref> Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration.<ref name="Ma">PMID:26620255</ref> GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.<ref name="Burant">PMID:23882043</ref>

Sandbox Reserved 1170: Difference between revisions

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Revision as of 13:50, 29 March 2016 view source Jacob Applegarth (talk \| contribs) 96 edits No edit summary ← Older edit		Revision as of 18:53, 29 March 2016 view source Whitney Hart (talk \| contribs) 186 edits No edit summary Newer edit →
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	== Background ==		== Background ==
	Human G-protein coupled receptor 40 (hGPR40), also known as free fatty acid 1 receptor (FFAR1), is a seven helical transmembrane domain receptor for long-chain free fatty acids that stimulates [[insulin]] secretion.<ref name="Srivastava">PMID:25043059</ref> This [http://www.britannica.com/science/enzyme enzyme] is primarily located in the [https://en.wikipedia.org/wiki/Beta_cell pancreatic β-cells] in the [https://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans], and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments].<ref name="Kebede">PMID:22308370</ref> Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration.<ref name="Ma">PMID:26620255</ref> GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.<ref name="Burant">PMID:23882043</ref>		Human G-protein coupled receptor 40 (hGPR40), also known as free fatty acid 1 receptor (FFAR1), is a seven helical transmembrane domain receptor for long-chain free fatty acids that stimulates [[insulin]] secretion.<ref name="Srivastava">PMID:25043059</ref> Some known fatty acid substrates of hGPR40 include linoleic acid, oleic acid, eicosatrienoic acid, and palmitoleic acid. This [http://www.britannica.com/science/enzyme enzyme] is primarily located in the [https://en.wikipedia.org/wiki/Beta_cell pancreatic β-cells] in the [https://en.wikipedia.org/wiki/Pancreatic_islets islets of Langerhans], and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments].<ref name="Kebede">PMID:22308370</ref> Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration.<ref name="Ma">PMID:26620255</ref> GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.<ref name="Burant">PMID:23882043</ref>