Sandbox Reserved 1160: Difference between revisions
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*Asparagine 747forms a hydrogen bond network with main chain carbonyl of Glycine 652 and the carbamate portion of mavoglurant. | *Asparagine 747forms a hydrogen bond network with main chain carbonyl of Glycine 652 and the carbamate portion of mavoglurant. | ||
*Bicyclic ring surrounded by <scene name='72/721531/Protien_hydrophobic/1'>hydrophobic binding pocket</scene>. | *Bicyclic ring surrounded by <scene name='72/721531/Protien_hydrophobic/1'>hydrophobic binding pocket</scene>. | ||
*2 Catalytic serine resides H-bond to the hyrdoxyl oxygen. | *2 Catalytic <scene name='72/721531/Protien_bindmiddle/1'>serine</scene> resides H-bond to the hyrdoxyl oxygen of our ligand. | ||
*A water molecular inside of the binding pocket helps stabilize the inactive state. | *A <scene name='72/721531/Protien_bindbottom/1'>water molecular</scene> inside of the binding pocket helps stabilize the inactive state. | ||
Once bound to Mavoglurant, the whole domain undergoes a conformational change to | Once bound to Mavoglurant, the whole domain undergoes a conformational change to | ||
