Sandbox Reserved 1174: Difference between revisions
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== Endocannabinoids == | == Endocannabinoids == | ||
The endocannabinoid system, located in the mammalian nervous system, regulates a variety of physiological processes including appetite, pain sensation, mood, and memory. Endocannabinoids, the natural ligands for cannabinoid receptors, are similar in structure to lysophosphatidic acid. Both the cannabinoid receptors and the LPA receptors have a preference for long unsaturated acyl chains. | The endocannabinoid system, located in the mammalian nervous system, regulates a variety of physiological processes including appetite, pain sensation, mood, and memory. Endocannabinoids, the natural ligands for cannabinoid receptors, are similar in structure to lysophosphatidic acid.<ref name= "Chrencik"/> Both the cannabinoid receptors and the LPA receptors have a preference for long unsaturated acyl chains. The polar amino acid <scene name='72/721545/210/1'>Trp210</scene> in the binding pocket is unique to the lysophospholipid and cannabinoid receptors. | ||
Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications. | A major cannabinoid signaling molecule, 2-arachidonyl glycerol (2-AG), can be phosphorylated into 2-arachidonyl phosphatidic acid (2-ALPA). 2-ALPA has a similar structure to LPA (Figure 4), and is able to bind in the LPA<sub>1</sub> receptor binding pocket. Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications. 2-ALPA is able to cause the same downstream signaling that the LPA molecule does. | ||
== References == | == References == | ||
<references/> | <references/> | ||
