Sandbox Reserved 1161: Difference between revisions
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== Function and Pathway == | == Function and Pathway == | ||
It all begins with glutamate binding to the venus fly trap domain. The signal transduction goes across the cystine-rich domain to the TMD. Next the dimerization of the TMD occurs. This activates the Gq/11 pathway, which activates phspholipase Cβ. The active phospholipase Cβ performs hydrolysis on phosphotinositides and generates inositol 1,4,5-trisphosphate and diacyl-glycerol. This results in calcium mobilization and activation of protein kinase C. (Niswender, Colleen M..(2010). "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease." Annu. Rev. Pharmacol. Toxicol. Annual Review of Pharmacology and Toxicology 50.1: 295-322.) | It all begins with glutamate binding to the venus fly trap domain. The signal transduction goes across the cystine-rich domain to the TMD. Next the dimerization of the TMD occurs. This activates the Gq/11 pathway, which activates phspholipase Cβ. The active phospholipase Cβ performs hydrolysis on phosphotinositides and generates [https://pubchem.ncbi.nlm.nih.gov/compound/439456#section=Top/ inositol 1,4,5-trisphosphate] and [https://en.wikipedia.org/wiki/Diglyceride/ diacyl-glycerol]. This results in calcium mobilization and activation of protein kinase C. (Niswender, Colleen M..(2010). "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease." Annu. Rev. Pharmacol. Toxicol. Annual Review of Pharmacology and Toxicology 50.1: 295-322.) | ||
== Disease == | == Disease == | ||
