Sandbox reserved 1169: Difference between revisions
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==Neurotensin Receptor (''Rattus norvegicus'')== | ==Neurotensin Receptor (''Rattus norvegicus'')== | ||
<StructureSection load='4GRV2.pdb' size='340' frame= 'true' align='right' caption='Neurotensin G-Protein Coupled Receptor (PDB Codes [http://www.rcsb.org/pdb/explore/explore.do?structureId=4GRV 4GRV] and [http://www.rcsb.org/pdb/explore/explore.do?structureId=4XEE 4XEE])' scene='72/ | <StructureSection load='4GRV2.pdb' size='340' frame= 'true' align='right' caption='Neurotensin G-Protein Coupled Receptor (PDB Codes [http://www.rcsb.org/pdb/explore/explore.do?structureId=4GRV 4GRV] and [http://www.rcsb.org/pdb/explore/explore.do?structureId=4XEE 4XEE])' <scene name='72/727765/Overall_structure/2'></scene> | ||
== Introduction == | == Introduction == | ||
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone [https://en.wikipedia.org/wiki/Neurotensin neurotensin (NTS)]. There are currently around 800 G protein-coupled receptors that have been identified and are thought to be responsible for roughly 80% of [https://en.wikipedia.org/wiki/Signal_transduction signal transduction] across the cell membrane.<ref name="Millar">PMID:20019124</ref> These receptors are involved in a vast array of physiological processes within the body that range from interactions with [https://en.wikipedia.org/wiki/Dopamine dopamine] to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become a major site of drug targets in medicine making a deeper, more in depth understanding of these proteins very important. <ref name="Fang">PMID:23573662</ref> There are currently no NTRS1 structures of the inactive state, so there is no way to determine the [https://en.wikipedia.org/wiki/Conformational_change conformational change] of the binding pocket caused by the binding of NTS. <ref name="White">PMID:23051748</ref> | The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as [http://proteopedia.org/wiki/index.php/G_protein-coupled_receptor G protein-coupled receptors] (GPCRs) and responds to the 13 amino acid hormone [https://en.wikipedia.org/wiki/Neurotensin neurotensin (NTS)]. There are currently around 800 G protein-coupled receptors that have been identified and are thought to be responsible for roughly 80% of [https://en.wikipedia.org/wiki/Signal_transduction signal transduction] across the cell membrane.<ref name="Millar">PMID:20019124</ref> These receptors are involved in a vast array of physiological processes within the body that range from interactions with [https://en.wikipedia.org/wiki/Dopamine dopamine] to effects on secretion of bile in the intestines.<ref name="Gui">PMID:11208724</ref> <ref name="Binder">PMID:1173461</ref> Due to the vast array of functions that these proteins serve and their high abundance within the body, these proteins have become a major site of drug targets in medicine making a deeper, more in depth understanding of these proteins very important. <ref name="Fang">PMID:23573662</ref> There are currently no NTRS1 structures of the inactive state, so there is no way to determine the [https://en.wikipedia.org/wiki/Conformational_change conformational change] of the binding pocket caused by the binding of NTS. <ref name="White">PMID:23051748</ref> | ||
