Sandbox Reserved 1172: Difference between revisions
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== Introduction == | == Introduction == | ||
Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>) that bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref> | Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA<sub>1</sub>) is a [[G protein-coupled receptor]] and one of 6 different LPA receptors (LPA<sub>1</sub>-LPA<sub>6</sub>) that bind the phospholipid derivative [https://en.wikipedia.org/wiki/Lysophosphatidic_acid lysophosphatidic acid (LPA)], a signaling molecule that acts as a potent [https://en.wikipedia.org/wiki/Mitogen mitogen] upon binding to one of its six receptors.<ref name="regpeps">PMID: 26091040</ref>. LPA<sub>1</sub> is part of the larger [http://jb.oxfordjournals.org/content/131/6/767 EDG receptor family] which includes the more widely known sphingosine 1-phopshate receptors. | ||
== Structure == | == Structure == | ||
[[Image:ABP.png|250 px|left|thumb|Electrostatic illustration of the amphipathic binding pocket of the LPA<sub>1</sub> receptor.]] | [[Image:ABP.png|250 px|left|thumb|Electrostatic illustration of the amphipathic binding pocket of the LPA<sub>1</sub> receptor.]] | ||
