Sandbox Reserved 1160: Difference between revisions
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== Pathway == | == Pathway == | ||
It all begins with glutamate binding to the Venus flytrap domain. The signal is transduced across the cystine-rich domain to the TMD. Next, the dimerization of the TMD occurs. This activates the Gq/11 pathway, which activates phspholipase Cβ<ref name="Niswender" />. The active phospholipase Cβ hydrolyzes phosphotinositides and generates inositol 1,4,5-trisphosphate and diacyl-glycerol<ref name="Woodcock" />. This results in calcium mobilization and activation of PKC<ref name="Niswender" />. | It all begins with glutamate binding to the Venus flytrap domain. The signal is transduced across the cystine-rich domain to the TMD. Next, the dimerization of the TMD occurs. This activates the Gq/11 pathway, which activates phspholipase Cβ<ref name="Niswender" />. The active phospholipase Cβ hydrolyzes phosphotinositides and generates [https://pubchem.ncbi.nlm.nih.gov/compound/439456#section=Top/ inositol 1,4,5-trisphosphate] and [https://en.wikipedia.org/wiki/Diglyceride/ diacyl-glycerol]<ref name="Woodcock" />. This results in calcium mobilization and activation of PKC<ref name="Niswender" />. | ||
== Disease == | == Disease == | ||
