Sandbox Reserved 425: Difference between revisions

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• FGFR-4 is abundantly present in human prostate cancer
• FGFR-4 is abundantly present in human prostate cancer


•Variant of FGFR-4 with (Arg(388)) replacing (Gly(388)) is associated with increased human prostate cancer. This causes increased receptor stability and activation. [2]
•Variant of FGFR-4 with (Arg(388)) replacing (Gly(388)) is associated with increased human prostate cancer. This causes increased receptor stability and activation<ref name="three">PMID: 18670643</ref>


<scene name='48/483882/Hydrophobicity_and_residue_388/1'>Hydrophobicity and Residue 388</scene>
<scene name='48/483882/Hydrophobicity_and_residue_388/1'>Hydrophobicity and Residue 388</scene>
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==References==
==References==
<references/>
<references/>
[1]  Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR. Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. J Biol Chem. 1993 Mar 15;268(8):5388-94. PMID:http://www.ncbi.nlm.nih.gov/pubmed/7680645
[2] Wang J, Yu W, Cai Y, Ren C, Ittmann MM. Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. Neoplasia. 2008 Aug;10(8):847-56. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18670643
[3] Tucker, J. A.; Klein, T.; Breed, J.; Breeze, A. L.; Overman, R.; Phillips, C.; Norman, R. A. Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4. Structure 2014, 22, 1764-1774.


[4] Huang, Zhifeng et al. "DFG-Out Mode Of Inhibition By An Irreversible Type-1 Inhibitor Capable Of Overcoming Gate-Keeper Mutations In FGF Receptors". ACS Chem. Biol. 10.1 (2015): 299-309. Web.
[4] Huang, Zhifeng et al. "DFG-Out Mode Of Inhibition By An Irreversible Type-1 Inhibitor Capable Of Overcoming Gate-Keeper Mutations In FGF Receptors". ACS Chem. Biol. 10.1 (2015): 299-309. Web.
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