1h6i: Difference between revisions
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1''' | '''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1''' | ||
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[[Category: Groot, B L.De.]] | [[Category: Groot, B L.De.]] | ||
[[Category: Grubmuller, H.]] | [[Category: Grubmuller, H.]] | ||
[[Category: | [[Category: Electron diffraction]] | ||
[[Category: | [[Category: Electron microscopy]] | ||
[[Category: | [[Category: Membrane protein]] | ||
[[Category: | [[Category: Two-dimensional crystal]] | ||
[[Category: | [[Category: Water channel]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:42 2008'' | |||
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Revision as of 15:29, 2 May 2008
A REFINED STRUCTURE OF HUMAN AQUAPORIN 1
Overview
A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
About this Structure
1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455 Page seeded by OCA on Fri May 2 18:29:42 2008
