Sandbox Reserved 431: Difference between revisions
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==Overall Structure== | ==Overall Structure== | ||
Cytochrome P450 exists as an <scene name='48/483888/Cytochrome_p450_dimer/1'>asymmetric dimer</scene>. Each dimeric unit contains 12 α-helices (labeled A-L) along with β-sheets, which are mostly located on one side of the molecule. Helices F and G form the dimeric interface of cytochrome P450, and are also involved in the formation of the active site. | Cytochrome P450 exists as an <scene name='48/483888/Cytochrome_p450_dimer/1'>asymmetric dimer</scene>. Each dimeric unit contains 12 α-helices (labeled A-L) along with β-sheets, which are mostly located on one side of the molecule. Helices F and G from each of the two units form the dimeric interface of cytochrome P450, and are also involved in the formation of the active site. This dimeric interface of the protein is stabilized by <scene name='48/483888/Cytochrome_p450_interface/1'>hydrogen bonding interactions</scene> between the G helix of one the units with the F helix of the second unit, and vice versa. Two molecules of 2-hydroxypropyl-β-cyclodextrin, which is used to dissolve vitamin D3, are also found near the dimer interface. | ||
==Binding Interactions== | ==Binding Interactions== | ||
