Sandbox Reserved 1174: Difference between revisions
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== Endocannabinoids == | == Endocannabinoids == | ||
The endocannabinoid system | The endocannabinoid system regulates a variety of physiological processes including appetite, pain sensation, mood, and memory. Endocannabinoids, the natural ligands for cannabinoid receptors, are similar in structure to lysophosphatidic acid.<ref name= "Chrencik"/> Both the cannabinoid receptors and the LPA receptors have a preference for long unsaturated acyl chains.<ref name= "Chrencik"/> The polar amino acid <scene name='72/721545/210/1'>Trp210</scene> in the binding pocket is unique to the lysophospholipid and cannabinoid receptors. | ||
[[Image:2-AG.png|220px|right|thumb|'''Figure 4:''' 2-arachidonylglycerol]] | [[Image:2-AG.png|220px|right|thumb|'''Figure 4:''' 2-arachidonylglycerol (2-AG)]] | ||
A major cannabinoid signaling molecule, 2-arachidonyl glycerol (2-AG, Figure 4), can be phosphorylated into 2-arachidonyl phosphatidic acid (2-ALPA). 2-ALPA has a similar structure to LPA, and is able to bind in the LPA<sub>1</sub> receptor binding pocket. 2-ALPA binding to LPA<sub>1</sub> causes the same downstream signaling that the LPA molecule does, effectively connecting these two systems. Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications.<ref name= "Chrencik"/> | A major cannabinoid signaling molecule, 2-arachidonyl glycerol (2-AG, Figure 4), can be phosphorylated into 2-arachidonyl phosphatidic acid (2-ALPA). 2-ALPA has a similar structure to LPA, and is able to bind in the LPA<sub>1</sub> receptor binding pocket. 2-ALPA binding to LPA<sub>1</sub> causes the same downstream signaling that the LPA molecule does, effectively connecting these two systems. Promiscuous ligand binding between these two pathways has potential functional and therapeutic implications.<ref name= "Chrencik"/> | ||
