Sandbox Reserved 1174: Difference between revisions

Many of the functions of LPA₁, i.e. cell proliferation, survival, and morphology, are implicated in cancers. LPA has been shown to act as a tumor mitogen and an inducer of tumor-derived cytokine to support the metastasis (spreading) of breast and ovarian cancer to bones. Inhibition of LPA₁ can significantly reduce this progression, and therefore may be a promising treatment for patients with bone metastasis. <ref name= "Boucharaba"> DOI: 10.1073/pnas.0600979103 </ref> It has not been shown to have an effect on primary tumor size. <ref name= "Jean > DOI: 10.1093/jnci/djs319 </ref>