Sandbox Reserved 1174: Difference between revisions

To gain a better understand the role the LPA plays in fibrosis, a study was done with mice who had contracted fibrosis <ref name= "Tager"> PMID:18066075 </ref>.  Idiopathic pulmonary fibrosis (IPF) has high rates of mortality.  Research has been done to study the pathway of the LPA-LPA₁ in fibroblast migration ([https://en.wikipedia.org/wiki/Wound_healing Wound Healing]).  In the injured lungs, the IPF, fibroblast can be activated.  In the lungs genes related to cell migration can be unregulated.  The fibroblast migration can be regulated by LPA.  The bronchoalveolar lavage (BAL) in mice that had fibrosis was elevated. The research supported the hypothesis that LPA₁ plays an active role between lung injury and contracting pulmonary fibrosis.  LPA has the ability to lead to a vascular leak after an initial injury which can lead to fibrosis.  This study's findings shows that LPA₁ is part of a link between lung injury and [http://www.nature.com/nm/journal/v14/n1/fig_tab/nm1685_F4.html pulmonary fibrosis] <ref name= "Tager"/>.