Sandbox Reserved 1167: Difference between revisions
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A conserved [https://en.wikipedia.org/wiki/Disulfide disulfide bond] can be found in 7tm region at <scene name='72/721538/7tm_disulfide_bond/2'>Cys224-Cys294</scene> which helps to stabilize the 7tm fold. This bond is conserved among both class A and class B receptors. Additionally, the ECD region of Class B GCPRs is defined by three conserved disulfide bonds. These bonds occur at <scene name='72/721538/Ecd_disulfide_bond_1/4'>Cys62-Cys104</scene>, <scene name='72/721538/Ecd_disulfide_bond_2/1'>Cys46-Cys71</scene>, and <scene name='72/721538/Ecd_disulfide_bond_3/1'>Cys85-Cys126</scene>. | A conserved [https://en.wikipedia.org/wiki/Disulfide disulfide bond] can be found in 7tm region at <scene name='72/721538/7tm_disulfide_bond/2'>Cys224-Cys294</scene> which helps to stabilize the 7tm fold. This bond is conserved among both class A and class B receptors. Additionally, the ECD region of Class B GCPRs is defined by three conserved disulfide bonds. These bonds occur at <scene name='72/721538/Ecd_disulfide_bond_1/4'>Cys62-Cys104</scene>, <scene name='72/721538/Ecd_disulfide_bond_2/1'>Cys46-Cys71</scene>, and <scene name='72/721538/Ecd_disulfide_bond_3/1'>Cys85-Cys126</scene>. | ||
As a part of the interface stabilization between helices VI, V, and III, a Class B-specific [https://en.wikipedia.org/wiki/Hydrogen_bond hydrogen bond] occurs between [https://en.wikipedia.org/wiki/Asparagine Asn] 318 of Helix V and [https://en.wikipedia.org/wiki/Leucine Leu] 242 of Helix III. | As a part of the interface <scene name='72/721537/Helical_interactions_vi-v-iii/1'>stabilization</scene> between helices VI, V, and III, a Class B-specific [https://en.wikipedia.org/wiki/Hydrogen_bond hydrogen bond] occurs between [https://en.wikipedia.org/wiki/Asparagine Asn] 318 of Helix V and [https://en.wikipedia.org/wiki/Leucine Leu] 242 of Helix III. | ||
=== GCGR-Specific Traits === | === GCGR-Specific Traits === | ||
