Sandbox 465: Difference between revisions
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== Structure == | == Structure == | ||
To carry out enzymatic activities, STK11 forms a heterotrimeric complex with STE20-related adaptor (STRAD) and mouse protein 25 (MO25). STRAD, a pseudokinase, induces a conformational change of STK11 into its catalytically active state and transports STK11 from the nucleus to the cytoplasm. MO25, a scaffold protein, strengthens the binding of STK11 and STRAD, and as a result enhances STRAD’s effect on STK11’s kinase activity. | To carry out enzymatic activities, STK11 forms a heterotrimeric complex with STE20-related adaptor (STRAD) and mouse protein 25 (MO25). STRAD, a pseudokinase, induces a conformational change of STK11 into its catalytically active state and transports STK11 from the nucleus to the cytoplasm. MO25, a scaffold protein, strengthens the binding of STK11 and STRAD, and as a result enhances STRAD’s effect on STK11’s kinase activity. | ||
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