1hb6: Difference between revisions
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{{STRUCTURE_1hb6| PDB=1hb6 | SCENE= }} | |||
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'''STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN ORTHORHOMBIC CRYSTAL FORM''' | '''STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN ORTHORHOMBIC CRYSTAL FORM''' | ||
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==About this Structure== | ==About this Structure== | ||
1HB6 is a [[Single protein]] structure | 1HB6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HB6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Knudsen, J.]] | [[Category: Knudsen, J.]] | ||
[[Category: Zou, J Y.]] | [[Category: Zou, J Y.]] | ||
[[Category: | [[Category: Acyl-coa]] | ||
[[Category: | [[Category: Binding protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:39:41 2008'' | |||
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Revision as of 15:39, 2 May 2008
STRUCTURE OF BOVINE ACYL-COA BINDING PROTEIN IN ORTHORHOMBIC CRYSTAL FORM
Overview
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. The biochemical properties of Plasmodium falciparum ACBP are described together with the 2.0 A resolution crystal structures of a P. falciparum ACBP-acyl-CoA complex and of bovine ACBP in two crystal forms. Overall, the bovine ACBP crystal structures are similar to the NMR structures published previously; however, the bovine and parasite ACBP structures are less similar. The parasite ACBP is shown to have a different ligand-binding pocket, leading to an acyl-CoA binding specificity different from that of bovine ACBP. Several non-conservative differences in residues that interact with the ligand were identified between the mammalian and parasite ACBPs. These, together with measured binding-specificity differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site.
About this Structure
1HB6 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein., van Aalten DM, Milne KG, Zou JY, Kleywegt GJ, Bergfors T, Ferguson MA, Knudsen J, Jones TA, J Mol Biol. 2001 May 25;309(1):181-92. PMID:11491287 Page seeded by OCA on Fri May 2 18:39:41 2008
