Sandbox WWC3: Difference between revisions

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It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion. The other two water molecules would be axial to the sodium ion. Full rehydration would occur when the ion moves next to the LEU and THR residues. Full rehydration then allows the sodium ion to enter the cytoplasm.

To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is ~~___~~, GLU 177 is ~~_____~~ and SER 178 is ~~____~~.

To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black.

Sandbox WWC3: Difference between revisions

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Revision as of 00:37, 17 April 2016 view source Landon Edwards (talk \| contribs) 63 edits No edit summary ← Older edit		Revision as of 00:41, 17 April 2016 view source Landon Edwards (talk \| contribs) 63 edits No edit summary Newer edit →
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	It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion. The other two water molecules would be axial to the sodium ion. Full rehydration would occur when the ion moves next to the LEU and THR residues. Full rehydration then allows the sodium ion to enter the cytoplasm.		It is likely that the sodium ion can get much closer to the channel than a larger K+ ion. When the ion reaches this distance, there is a more efficient removal of water and the sodium interacts with the Glu117 side chains. Two side chains interact directly with the sodium ion and two side chains form hydrogen bonds with the water molecules <ref name= "crystal"/>. The pore is made up of THR 175, LEU 176, GLU 177 and SER 178 <ref name= "crystal"/>. The GLU side chains act as hydrogen bond acceptors two in-plane molecules surrounding the sodium ion. The other two water molecules would be axial to the sodium ion. Full rehydration would occur when the ion moves next to the LEU and THR residues. Full rehydration then allows the sodium ion to enter the cytoplasm.

	To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is ~~___~~, GLU 177 is ~~_____~~ and SER 178 is ~~____~~.		To see the selectivity filter, click <scene name='69/696300/Selectivity_pore/2'>here</scene>. THR 175 is blue, LEU 176 is yellow, GLU 177 is red and SER 178 is black.