Sandbox Reserved 1165: Difference between revisions

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===Introduction===

'''Human glucagon class B G protein-coupled receptors (GPCRs'''), also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily GPCRs and very similar in structure to the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family. <ref name="Intro">PMID: 24359917</ref> Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon]. Glucagon binding leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and an [https://en.wikipedia.org/wiki/Liver extracellular domain] (ECD) that are required for glucagon binding.

'''Human glucagon class B G protein-coupled receptors (GPCRs'''), also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of GPCRs and very similar in structure to the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family. <ref name="Intro">PMID: 24359917</ref> Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon]. Glucagon binding leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and an [https://en.wikipedia.org/wiki/Liver extracellular domain] (ECD) that are required for glucagon binding.

Sandbox Reserved 1165: Difference between revisions

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Revision as of 16:56, 18 April 2016 view source Steven Bennett (talk \| contribs) 218 edits No edit summary ← Older edit		Revision as of 17:01, 18 April 2016 view source Steven Bennett (talk \| contribs) 218 edits No edit summary Newer edit →
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	===Introduction===		===Introduction===
	'''Human glucagon class B G protein-coupled receptors (GPCRs'''), also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily GPCRs and very similar in structure to the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family. <ref name="Intro">PMID: 24359917</ref> Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon]. Glucagon binding leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and an [https://en.wikipedia.org/wiki/Liver extracellular domain] (ECD) that are required for glucagon binding.		'''Human glucagon class B G protein-coupled receptors (GPCRs'''), also known as [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin-like receptors], are a subfamily of GPCRs and very similar in structure to the more well known class A ([https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin-like]) glucagon receptor family. <ref name="Intro">PMID: 24359917</ref> Located in the [https://en.wikipedia.org/wiki/Liver liver], class B glucagon receptors (GCGRs) are activated by the binding of the hormonal peptide [https://en.wikipedia.org/wiki/Glucagon glucagon]. Glucagon binding leads to the release of [https://en.wikipedia.org/wiki/Glucose glucose] into the [https://en.wikipedia.org/wiki/Circulatory_system bloodstream] and plays an essential role in [https://en.wikipedia.org/wiki/Blood_sugar_regulation glucose homeostasis]. Class B GCGRs are composed of a [https://en.wikipedia.org/wiki/Liver seven transmembrane domain] (7TM) and an [https://en.wikipedia.org/wiki/Liver extracellular domain] (ECD) that are required for glucagon binding.