Sandbox Reserved 1174: Difference between revisions
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===Pain=== | ===Pain=== | ||
When an injury occurs LPA is released in the body. LPA will then activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA <ref name= "Inoue">. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK) <ref name= "Inoue">. The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain. When ROCK was inhibited the remaining pathway no longer functioned normally. Mice with the deletion of LPA<sub>1</sub> receptors had lower levels of pain <ref name= "Inoue" | When an injury occurs LPA is released in the body. LPA will then activate G-protein-coupled receptors. Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle). The LPA signaling will activate GTPase RhoA <ref name= "Inoue"> DOI:10.1038/nm1060 </ref>. Once activated Rho translocates to the plasma membrane. Rho will activate Rho kinase (ROCK) <ref name= "Inoue"/>. The actiavtion of ROCK is a required step in the pathway in the stimulation of neurotic pain. When ROCK was inhibited the remaining pathway no longer functioned normally. Mice with the deletion of LPA<sub>1</sub> receptors had lower levels of pain <ref name= "Inoue"/>. | ||
=== Fibrosis === | === Fibrosis === | ||
