Sandbox 78: Difference between revisions

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== Introduction ==

Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is the [[lipase]] that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>. This acid-stable enzyme <ref name="gastritis">PMID:23899880</ref> is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults <ref name="armand" />. HGL specifically catalyzes the hydrolysis of triacylglycerol in order to produce diacylglycerol and a carboxylate byproduct <ref name="roussel">PMID:10358049</ref>, a process that facilitates subsequent fat breakdown by pancreatic lipase <ref name="dogs">PMID:20965171</ref>. In terms of disease implications, there is evidence to suggest that HGL secretion is altered in individuals with gastritis <ref name="gastritis" />.

Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is the [[lipase]] that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>. This acid-stable enzyme <ref name="gastritis">PMID:23899880</ref> is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults <ref name="armand" />. HGL specifically catalyzes the hydrolysis of triacylglycerol in order to produce diacylglycerol and a carboxylate byproduct <ref name="roussel">PMID:10358049</ref>, a process that facilitates subsequent fat breakdown by pancreatic lipase <ref name="dogs">PMID:20965171</ref>. In terms of disease implications, there is evidence to suggest that HGL secretion is altered in individuals with gastritis (the most common gastric condition, in which the stomach lining is inflamed) <ref name="gastritis" />.

== Structural highlights ==

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== Relevance to Human Health & Disease ==

Tomasik et al. (2013) <ref name="gastritis" /> investigated the hormonal regulation of HGL secretion in children and adolescents with gastritis ~~(the most common gastric condition, in which the stomach lining is inflamed)~~. HGL activity was compared across three groups: one experimental group consisting of adolescents diagnosed with Helicobacter pylori gastritis (n = 10), another experimental group consisting of adolescents with a non-H. pylori induced form of gastritis (n = 10), and one control group of healthy adolescents (n = 14). HGL activity, in addition to plasma concentrations of glucagon-like peptide-1, cholecystokinin, and glucose-dependent insulinotropic peptide, were observed through analysis of gastric juice samples that had been collected via endoscopic measurements from each patient.

Tomasik et al. (2013) <ref name="gastritis" /> investigated the hormonal regulation of HGL secretion in children and adolescents with gastritis. HGL activity was compared across three groups: one experimental group consisting of adolescents diagnosed with ''Helicobacter pylori'' gastritis (''n'' = 10), another experimental group consisting of adolescents with a non-''H. pylori'' induced form of gastritis (''n'' = 10), and one control group of healthy adolescents (''n'' = 14). HGL activity, in addition to plasma concentrations of glucagon-like peptide-1, cholecystokinin, and glucose-dependent insulinotropic peptide, were observed through analysis of gastric juice samples that had been collected via endoscopic measurements from each patient.

Patients whose superficial gastritis was induced by pathogens other than H. pylori exhibited lower levels of HGL activity compared to both healthy adolescents (p < .005) and those who were diagnosed with H. pylori gastritis (p < .005). Mean plasma concentrations of glucose-dependent insulinotropic peptide were lower in healthy patients (p < 0.005) than in those with non-H. pylori gastritis (p < .003) and those with H. pylori gastritis (p < 0.01). Regulation of HGL secretion by glucagon-like peptide-1 and cholecystokinin was therefore found to be altered in adolescents with gastritis. In addition, glucose-dependent insulinotropic peptide was found to be a powerful activator of human gastric lipase activity in all experimental and control groups <ref name="gastritis" />.

Patients whose superficial gastritis was induced by pathogens other than ''H. pylori'' exhibited lower levels of HGL activity compared to both healthy adolescents (''p'' < .005) and those who were diagnosed with ''H. pylori'' gastritis (''p'' < .005). Mean plasma concentrations of glucose-dependent insulinotropic peptide were lower in healthy patients (''p'' < 0.005) than in those with non-''H. pylori'' gastritis (''p'' < .003) and those with ''H. pylori'' gastritis (''p'' < 0.01). Regulation of HGL secretion by glucagon-like peptide-1 and cholecystokinin was therefore found to be altered in adolescents with gastritis. In addition, glucose-dependent insulinotropic peptide was found to be a powerful activator of human gastric lipase activity in all experimental and control groups <ref name="gastritis" />.

== References ==

Sandbox 78: Difference between revisions

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 == Introduction ==
-Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is the [[lipase]] that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>. This acid-stable enzyme <ref name="gastritis">PMID:23899880</ref> is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults <ref name="armand" />. HGL specifically catalyzes the hydrolysis of triacylglycerol in order to produce diacylglycerol and a carboxylate byproduct <ref name="roussel">PMID:10358049</ref>, a process that facilitates subsequent fat breakdown by pancreatic lipase <ref name="dogs">PMID:20965171</ref>. In terms of disease implications, there is evidence to suggest that HGL secretion is altered in individuals with gastritis <ref name="gastritis" />.
+Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is the [[lipase]] that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>. This acid-stable enzyme <ref name="gastritis">PMID:23899880</ref> is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults <ref name="armand" />. HGL specifically catalyzes the hydrolysis of triacylglycerol in order to produce diacylglycerol and a carboxylate byproduct <ref name="roussel">PMID:10358049</ref>, a process that facilitates subsequent fat breakdown by pancreatic lipase <ref name="dogs">PMID:20965171</ref>. In terms of disease implications, there is evidence to suggest that HGL secretion is altered in individuals with gastritis (the most common gastric condition, in which the stomach lining is inflamed) <ref name="gastritis" />.
 == Structural highlights ==
@@ Line 19: / Line 19: @@
 == Relevance to Human Health & Disease ==
-Tomasik et al. (2013) <ref name="gastritis" /> investigated the hormonal regulation of HGL secretion in children and adolescents with gastritis (the most common gastric condition, in which the stomach lining is inflamed). HGL activity was compared across three groups: one experimental group consisting of adolescents diagnosed with Helicobacter pylori gastritis (n = 10), another experimental group consisting of adolescents with a non-H. pylori induced form of gastritis (n = 10), and one control group of healthy adolescents (n = 14). HGL activity, in addition to plasma concentrations of glucagon-like peptide-1, cholecystokinin, and glucose-dependent insulinotropic peptide, were observed through analysis of gastric juice samples that had been collected via endoscopic measurements from each patient.
+Tomasik et al. (2013) <ref name="gastritis" /> investigated the hormonal regulation of HGL secretion in children and adolescents with gastritis. HGL activity was compared across three groups: one experimental group consisting of adolescents diagnosed with ''Helicobacter pylori'' gastritis (''n'' = 10), another experimental group consisting of adolescents with a non-''H. pylori'' induced form of gastritis (''n'' = 10), and one control group of healthy adolescents (''n'' = 14). HGL activity, in addition to plasma concentrations of glucagon-like peptide-1, cholecystokinin, and glucose-dependent insulinotropic peptide, were observed through analysis of gastric juice samples that had been collected via endoscopic measurements from each patient.
-Patients whose superficial gastritis was induced by pathogens other than H. pylori exhibited lower levels of HGL activity compared to both healthy adolescents (p < .005) and those who were diagnosed with H. pylori gastritis (p < .005). Mean plasma concentrations of glucose-dependent insulinotropic peptide were lower in healthy patients (p < 0.005) than in those with non-H. pylori gastritis (p < .003) and those with H. pylori gastritis (p < 0.01).  Regulation of HGL secretion by glucagon-like peptide-1 and cholecystokinin was therefore found to be altered in adolescents with gastritis. In addition, glucose-dependent insulinotropic peptide was found to be a powerful activator of human gastric lipase activity in all experimental and control groups <ref name="gastritis" />.
+Patients whose superficial gastritis was induced by pathogens other than ''H. pylori'' exhibited lower levels of HGL activity compared to both healthy adolescents (''p'' < .005) and those who were diagnosed with ''H. pylori'' gastritis (''p'' < .005). Mean plasma concentrations of glucose-dependent insulinotropic peptide were lower in healthy patients (''p'' < 0.005) than in those with non-''H. pylori'' gastritis (''p'' < .003) and those with ''H. pylori'' gastritis (''p'' < 0.01).  Regulation of HGL secretion by glucagon-like peptide-1 and cholecystokinin was therefore found to be altered in adolescents with gastritis. In addition, glucose-dependent insulinotropic peptide was found to be a powerful activator of human gastric lipase activity in all experimental and control groups <ref name="gastritis" />.
 == References ==
 <references/>