Sandbox Reserved 1180: Difference between revisions
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=Glucagon G protein coupled receptor= | =Glucagon G protein coupled receptor= | ||
==Class B GPCRs | ==Class B GPCRs== | ||
<StructureSection load='4L6R' size='420' side='right' caption='7TM structure of human class B GPCR 4L6R', [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4L6R' size='420' side='right' caption='7TM structure of human class B GPCR 4L6R', [[Resolution|resolution]] 1.80Å' scene=''> | ||
G protein coupled receptors (GPCRs) are the largest class of integral membrane proteins. GPCRs are divided into five families; the rhodopsin family (class A), the secretin family (class B), the glutamate family (class C), the frizzled/taste family (class F), and the adhesion family.<ref name= "Zhang 2006"/> Roughly 5% of the human genome encodes g-protein-coupled receptors, which are responsible for the transduction of endogenous signals and the instigation of cellular responses. All GPCRs contain a similar seven α-helical transmembrane domain (TMD or 7TMD) that once bound to its ligand, undergoes a conformational change and tranduces a signal to coupled, heterotrimeric G proteins. The initiation of intracellular signal pathways occur in response to stimuli such as light, Ca2+, amino acids, nucleotides, odorants, peptides, and other proteins, [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor#Physiological_roles and accomplishes many interesting physiological roles]. <ref name= "Zhang 2006">DOI 10.1371/journal.pcbi.0020013</ref> | G protein coupled receptors (GPCRs) are the largest class of integral membrane proteins. GPCRs are divided into five families; the rhodopsin family (class A), the secretin family (class B), the glutamate family (class C), the frizzled/taste family (class F), and the adhesion family.<ref name= "Zhang 2006"/> Roughly 5% of the human genome encodes g-protein-coupled receptors, which are responsible for the transduction of endogenous signals and the instigation of cellular responses. All GPCRs contain a similar seven α-helical transmembrane domain (TMD or 7TMD) that once bound to its ligand, undergoes a conformational change and tranduces a signal to coupled, heterotrimeric G proteins. The initiation of intracellular signal pathways occur in response to stimuli such as light, Ca2+, amino acids, nucleotides, odorants, peptides, and other proteins, [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor#Physiological_roles and accomplishes many interesting physiological roles]. <ref name= "Zhang 2006">DOI 10.1371/journal.pcbi.0020013</ref> | ||
