Sandbox WWC8: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Dana Emmert (talk | contribs) No edit summary |
Dana Emmert (talk | contribs) No edit summary |
||
| Line 9: | Line 9: | ||
== Structural Features == | == Structural Features == | ||
The NP is a homo 3-mer - A3 with 499 amino acid residues | The NP is a homo 3-mer - A3 with 499 amino acid residues encoded by the Influenza A RNA segment 5. The globular protein is rich in arginine, serine, and glycine residues. The abundance of arginine residues gives the protein a net positive charge at pH 7. With a predicted pI of 9.3, NP is mainly composed of basic residues, except for a tail domain of the 30 C-terminal residues, which are acidic. The C-tail domain has a pI of 3.7. | ||
Each homomer provides a binding site for the viral RNA script. The homomers fold into a crescent shape with a head and a body domain, where the grove between the two domains hosts the ssRNA binding site on the outer surface of the homomer. [[Image:C:\Users\Tally\Desktop\NP monomer.jpg]] | |||
==Characterization of Possible Binding Interactions== | ==Characterization of Possible Binding Interactions== | ||
