STK11: Difference between revisions
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== Structure == | == Structure == | ||
STK11 has a molecular mass of approximately 50kDa and is the catalytically active unit of a heterotrimeric complex with | STK11 has a molecular mass of approximately 50kDa and is the catalytically active unit of a heterotrimeric complex with STRADA and MO25. STRADA, a pseudokinase, induces a conformational change in STK11 to form the catalytically active state which transports STK11 from the nucleus to the cytoplasm. MO25, a scaffold protein, strengthens the interaction between STK11 and STRAD, and as a result enhances the kinase activity of STK11 <ref> | ||
STK11. Genetics Home Reference. National Library of Medicine </ref>. STK11 has a <scene name='72/728131/Atp_binding_site/1'>ATP binding site</scene> located at Lys78, a basic amino acid, and a <scene name='72/728131/Nucleotide_binding_site/1'>nucleotide binding site</scene> (9 residues) consisting of hydrophobic amino acids (such as Gly, Leu, and Val), hydrophilic amino acids (such as Ser and Tyr), a basic amino acid (Lys), and an acidic amino acid (Glu). STK11 also has an <scene name='72/728131/Active_site_1/1'>active site</scene> at Asp176, which serves as a proton acceptor <ref> Gan RY, Li HB. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. International Journal of Molecular Science. 2014 Sep; 15(9):16698-16718. </ref>. | STK11. Genetics Home Reference. National Library of Medicine </ref>. STK11 has a <scene name='72/728131/Atp_binding_site/1'>ATP binding site</scene> located at Lys78, a basic amino acid, and a <scene name='72/728131/Nucleotide_binding_site/1'>nucleotide binding site</scene> (9 residues) consisting of hydrophobic amino acids (such as Gly, Leu, and Val), hydrophilic amino acids (such as Ser and Tyr), a basic amino acid (Lys), and an acidic amino acid (Glu). STK11 also has an <scene name='72/728131/Active_site_1/1'>active site</scene> at Asp176, which serves as a proton acceptor <ref> Gan RY, Li HB. Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive Function. International Journal of Molecular Science. 2014 Sep; 15(9):16698-16718. </ref>. | ||
