Sandbox WWC2: Difference between revisions

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== Inhibition and Research ==

Monoamine oxidase inhibitors (MAOIs) are among the most effective anti-depressants available, however, many inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. This is because MAO-A is responsible for oxidizing tyramine, a monoamine found in many different food and drink~~; the levels of tyramine~~ found ~~in the body can~~ have a strong effect on blood pressure. Due to MAO-As effect on blood pressure and digestion those ~~who~~ are ~~put on~~ MAOIs often have to follow a strict diet to prevent side effects such as dizziness, nausea, drowsiness, low blood pressure, and insomnia ~~do not occur~~. The diet requires that the patient avoid: alcohol, aged cheeses, cured meats, sauerkraut, tofu, fava beans, dried fruit, fermented soy products, any fish or meat refrigerated more than 24 hours [http://www.healthline.com/health/depression/monoamine-oxidase-inhibitors-maois].

Monoamine oxidase inhibitors (MAOIs) are among the most effective anti-depressants available, however, many of these inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. This is because MAO-A is responsible for oxidizing tyramine, a monoamine found in many different food and drink, has been found to have a strong effect on blood pressure. Due to MAO-As effect on blood pressure and digestion those whom are prescribed MAOIs often have to follow a strict diet to prevent side effects such as dizziness, nausea, drowsiness, low blood pressure, and insomnia. The diet requires that the patient avoid: alcohol, aged cheeses, cured meats, sauerkraut, tofu, fava beans, dried fruit, fermented soy products, any fish or meat refrigerated more than 24 hours [http://www.healthline.com/health/depression/monoamine-oxidase-inhibitors-maois]. Due to the affect MAOIs have on neurotransmitters and digestive enzymes they are rarely used as an antidepressant today, even though they are very effective when prescribed to individuals in which other anti-depressants have not worked.

A newer form of MAOI that has just recently come on the market, Selegiline, works by inhibiting primarily MAO-B as opposed to MAO-A; highly limiting the likeliness of side effects that are influenced by the excessive breakdown of tyramine. Isoform specific inhibitors are certainly a target for future research into treating MAO influenced disorders; particularly in child and adlolescent psychiatry [https://books.google.com/books?id=MEso7oyWMywC&pg=PA294&lpg=PA294&dq=future+research+in+monoamine+oxidase&source=bl&ots=FDX0pxkW6V&sig=xSSZ9HVigEdOTxEOTtyOti8_-oY&hl=en&sa=X&ved=0ahUKEwic4sCt5MPMAhULaT4KHWsmAOIQ6AEIVDAH#v=onepage&q=future%20research%20in%20monoamine%20oxidase&f=false].

~~== Structural highlights ==~~

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

~~</StructureSection>~~

== References ==

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@@ Line 29: / Line 29: @@
 == Inhibition and Research ==
-Monoamine oxidase inhibitors (MAOIs) are among the most effective anti-depressants available, however, many inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. This is because MAO-A is responsible for oxidizing tyramine, a monoamine found in many different food and drink; the levels of tyramine found in the body can have a strong effect on blood pressure. Due to MAO-As effect on blood pressure and digestion those who are put on MAOIs often have to follow a strict diet to prevent side effects such as dizziness, nausea, drowsiness, low blood pressure, and insomnia do not occur. The diet requires that the patient avoid: alcohol, aged cheeses, cured meats, sauerkraut, tofu, fava beans, dried fruit, fermented soy products, any fish or meat refrigerated more than 24 hours [http://www.healthline.com/health/depression/monoamine-oxidase-inhibitors-maois].
+Monoamine oxidase inhibitors (MAOIs) are among the most effective anti-depressants available, however, many of these inhibit MAO-A alongside the target MAO-B, which results in the need to be on a very strict diet while on MAOIs. This is because MAO-A is responsible for oxidizing tyramine, a monoamine found in many different food and drink, has been found to have a strong effect on blood pressure. Due to MAO-As effect on blood pressure and digestion those whom are prescribed MAOIs often have to follow a strict diet to prevent side effects such as dizziness, nausea, drowsiness, low blood pressure, and insomnia. The diet requires that the patient avoid: alcohol, aged cheeses, cured meats, sauerkraut, tofu, fava beans, dried fruit, fermented soy products, any fish or meat refrigerated more than 24 hours [http://www.healthline.com/health/depression/monoamine-oxidase-inhibitors-maois]. Due to the affect MAOIs have on neurotransmitters and digestive enzymes they are rarely used as an antidepressant today, even though they are very effective when prescribed to individuals in which other anti-depressants have not worked.
+A newer form of MAOI that has just recently come on the market, Selegiline, works by inhibiting primarily MAO-B as opposed to MAO-A; highly limiting the likeliness of side effects that are influenced by the excessive breakdown of tyramine. Isoform specific inhibitors are certainly a target for future research into treating MAO influenced disorders; particularly in child and adlolescent psychiatry [https://books.google.com/books?id=MEso7oyWMywC&pg=PA294&lpg=PA294&dq=future+research+in+monoamine+oxidase&source=bl&ots=FDX0pxkW6V&sig=xSSZ9HVigEdOTxEOTtyOti8_-oY&hl=en&sa=X&ved=0ahUKEwic4sCt5MPMAhULaT4KHWsmAOIQ6AEIVDAH#v=onepage&q=future%20research%20in%20monoamine%20oxidase&f=false].
-== Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
-</StructureSection>
 == References ==
 <references/>