1hmh: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1hmh.jpg|left|200px]]
[[Image:1hmh.jpg|left|200px]]


{{Structure
<!--
|PDB= 1hmh |SIZE=350|CAPTION= <scene name='initialview01'>1hmh</scene>, resolution 2.600&Aring;
The line below this paragraph, containing "STRUCTURE_1hmh", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1hmh| PDB=1hmh  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmh OCA], [http://www.ebi.ac.uk/pdbsum/1hmh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hmh RCSB]</span>
}}


'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''
'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''
Line 19: Line 16:


==About this Structure==
==About this Structure==
1HMH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA].  


==Reference==
==Reference==
Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7969422 7969422]
Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7969422 7969422]
[[Category: Protein complex]]
[[Category: Flaherty, K M.]]
[[Category: Flaherty, K M.]]
[[Category: McKay, D B.]]
[[Category: McKay, D B.]]
[[Category: Pley, H W.]]
[[Category: Pley, H W.]]
[[Category: dna-rna hammerhead ribozyme]]
[[Category: Dna-rna hammerhead ribozyme]]
[[Category: loop]]
[[Category: Loop]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:00:55 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:39 2008''

Revision as of 16:00, 2 May 2008

File:1hmh.jpg

Template:STRUCTURE 1hmh

THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME


Overview

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.

About this Structure

Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:7969422 Page seeded by OCA on Fri May 2 19:00:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1hmh&oldid=358809"