5is5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5is5 is ~~ON HOLD until Paper Publication~~

==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors==

~~Authors~~: ~~Gutmann~~, S., ~~Rummel~~, G., ~~Shrestha~~, B.

== Structural highlights ==

<table><tr><td colspan='2'>[[5is5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance].

~~Description: Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]

[[Category: Gutmann, S]]

[[Category: Rummel, G]]

[[Category: Shrestha, B]]

[[Category: Isoform-sepcific inhibitor]]

[[Category: Phosphoinositide 3-kinase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5is5 is ON HOLD  until Paper Publication
+==Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors==
+<StructureSection load='5is5' size='340' side='right' caption='[[5is5]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-Authors: Gutmann, S., Rummel, G., Shrestha, B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5is5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS5 FirstGlance]. <br>
-Description: Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CY:5-{4-[3-(4-ACETYLPIPERAZINE-1-CARBONYL)PHENYL]QUINAZOLIN-6-YL}-2-METHOXYPYRIDINE-3-CARBONITRILE'>6CY</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4,5-bisphosphate_3-kinase Phosphatidylinositol-4,5-bisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.153 2.7.1.153] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is5 OCA], [http://pdbe.org/5is5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is5 RCSB], [http://www.ebi.ac.uk/pdbsum/5is5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5is5 ProSAT]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
 [[Category: Gutmann, S]]
 [[Category: Rummel, G]]
 [[Category: Shrestha, B]]
+[[Category: Isoform-sepcific inhibitor]]
+[[Category: Phosphoinositide 3-kinase]]
+[[Category: Transferase]]