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'''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS''' | '''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS''' | ||
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[[Category: White, S W.]] | [[Category: White, S W.]] | ||
[[Category: Wilson, K S.]] | [[Category: Wilson, K S.]] | ||
[[Category: | [[Category: Alpha/beta class]] | ||
[[Category: | [[Category: Dna supercoiling]] | ||
[[Category: | [[Category: Dna-binding protein]] | ||
[[Category: | [[Category: Minor groove binder]] | ||
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Revision as of 16:15, 2 May 2008
DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS
Overview
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
About this Structure
1HUU is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
A protein structural motif that bends DNA., White SW, Appelt K, Wilson KS, Tanaka I, Proteins. 1989;5(4):281-8. PMID:2508086 Page seeded by OCA on Fri May 2 19:15:11 2008
