5j41: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5j41 ~~is ON HOLD until Paper Publication~~

==Glutathione S-transferase bound with hydrolyzed Piperlongumine==

~~Authors~~: ~~Harshbarger, W~~., ~~Gondi~~, S., ~~Ficarro~~, S., ~~Hunter~~, J., ~~Udayakumar~~, D., ~~Gurbani~~, D.~~, Marto, J~~.~~, Westover, K~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5j41]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J41 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J41 FirstGlance].

~~Description~~: Glutathione S~~-transferase bound with hydrolyzed Piperlongumine~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=3LF:3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC+ACID'>3LF</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j41 OCA], [http://pdbe.org/5j41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j41 RCSB], [http://www.ebi.ac.uk/pdbsum/5j41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j41 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Glutathione transferase]]

[[Category: Ficarro, S]]

[[Category: Gondi, S]]

[[Category: Gurbani, D]]

[[Category: Harshbarger, W]]

[[Category: Hunter, J]]

~~[[Category: Harshbarger, W]]~~

~~[[Category: Westover, K]]~~

[[Category: Marto, J]]

~~[[Category: Ficarro, S]]~~

~~[[Category: Gondi, S]]~~

[[Category: Udayakumar, D]]

[[Category: Westover, K]]

[[Category: Glutathione]]

[[Category: Gstp1]]

[[Category: Piperlongumine]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5j41 is ON HOLD  until Paper Publication
+==Glutathione S-transferase bound with hydrolyzed Piperlongumine==
+<StructureSection load='5j41' size='340' side='right' caption='[[5j41]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
-Authors: Harshbarger, W., Gondi, S., Ficarro, S., Hunter, J., Udayakumar, D., Gurbani, D., Marto, J., Westover, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5j41]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J41 FirstGlance]. <br>
-Description: Glutathione S-transferase bound with hydrolyzed Piperlongumine
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3LF:3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC+ACID'>3LF</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j41 OCA], [http://pdbe.org/5j41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j41 RCSB], [http://www.ebi.ac.uk/pdbsum/5j41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j41 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Glutathione transferase]]
+[[Category: Ficarro, S]]
+[[Category: Gondi, S]]
 [[Category: Gurbani, D]]
+[[Category: Harshbarger, W]]
 [[Category: Hunter, J]]
-[[Category: Harshbarger, W]]
-[[Category: Westover, K]]
 [[Category: Marto, J]]
-[[Category: Ficarro, S]]
-[[Category: Gondi, S]]
 [[Category: Udayakumar, D]]
+[[Category: Westover, K]]
+[[Category: Glutathione]]
+[[Category: Gstp1]]
+[[Category: Piperlongumine]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]