5j4a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5j4a is ~~ON HOLD until Paper Publication~~

==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein==

~~Authors~~: ~~Goulding~~, C.W., ~~Johnson~~, P.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J4A FirstGlance]. <br>

~~Description~~: ~~CdiA~~-CT ~~toxin from Burkholderia pseudomallei E479~~ in ~~complex with~~ cognate CdiI immunity ~~protein~~

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5j5v|5j5v]], [[5j43|5j43]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4a OCA], [http://pdbe.org/5j4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4a RCSB], [http://www.ebi.ac.uk/pdbsum/5j4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4a ProSAT]</span></td></tr>

[[Category: Johnson, P.M]]

</table>

[[Category: ~~Goulding, C.W~~]]

== Function ==

[[http://www.uniprot.org/uniprot/CDIA9_BURPE CDIA9_BURPE]] Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. The C-terminal 160 residues (CT domain) acts as a general tRNA nuclease, and inhibits growth in E.coli. Cleaves specifically within the T-loop of E.coli tRNA2(Arg). Toxic activity is neutralized by coexpression of the cognate immunity protein CdiI in E.coli, but not by non-cognate immunity proteins from other strains of B.pseudomallei.<ref>PMID:22435733</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Goulding, C W]]

[[Category: Johnson, P M]]

[[Category: Complex]]

[[Category: Endonuclease]]

[[Category: Immunity protein]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5j4a is ON HOLD  until Paper Publication
+==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein==
+<StructureSection load='5j4a' size='340' side='right' caption='[[5j4a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Goulding, C.W., Johnson, P.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J4A FirstGlance]. <br>
-Description: CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5j5v|5j5v]], [[5j43|5j43]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4a OCA], [http://pdbe.org/5j4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4a RCSB], [http://www.ebi.ac.uk/pdbsum/5j4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4a ProSAT]</span></td></tr>
-[[Category: Johnson, P.M]]
+</table>
-[[Category: Goulding, C.W]]
+== Function ==
+[[http://www.uniprot.org/uniprot/CDIA9_BURPE CDIA9_BURPE]] Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. The C-terminal 160 residues (CT domain) acts as a general tRNA nuclease, and inhibits growth in E.coli. Cleaves specifically within the T-loop of E.coli tRNA2(Arg). Toxic activity is neutralized by coexpression of the cognate immunity protein CdiI in E.coli, but not by non-cognate immunity proteins from other strains of B.pseudomallei.<ref>PMID:22435733</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Goulding, C W]]
+[[Category: Johnson, P M]]
+[[Category: Complex]]
+[[Category: Endonuclease]]
+[[Category: Immunity protein]]
+[[Category: Toxin]]