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'''Unreleased structure'''


The entry 5jh7 is ON HOLD
==Tubulin-Eribulin complex==
 
<StructureSection load='5jh7' size='340' side='right' caption='[[5jh7]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
Authors: Doodhi, H., Prota, A.E., Rodriguez-Garcia, R., Xiao, H., Custar, D.W., Bargsten, K., Katrukha, E.A., Hilbert, M., Hua, S., Jiang, K., Grigoriev, I., Yang, C.-P.H., Cox, D., Band Horwitz, S., Kapitein, L.C., Akhmanova, A., Steinmetz, M.O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5jh7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JH7 FirstGlance]. <br>
Description: Tubulin-Eribulin complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03S:METHANESULFONIC+ACID'>03S</scene>, <scene name='pdbligand=6K9:(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-AMINO-2-HYDROXYPROPYL]-21-METHOXY-14-METHYL-8,15-DIMETHYLIDENE-2,19,30,34,37,39,40,41-OCTAOXANONACYCLO[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]HENTETRACONTAN-24-ONE+(NON-PREFERRED+NAME)'>6K9</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jh7 OCA], [http://pdbe.org/5jh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jh7 RCSB], [http://www.ebi.ac.uk/pdbsum/5jh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jh7 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>  [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Akhmanova, A]]
[[Category: Bargsten, K]]
[[Category: Cox, D]]
[[Category: Cox, D]]
[[Category: Custar, D W]]
[[Category: Doodhi, H]]
[[Category: Grigoriev, I]]
[[Category: Grigoriev, I]]
[[Category: Akhmanova, A]]
[[Category: Hilbert, M]]
[[Category: Prota, A.E]]
[[Category: Horwitz, S Band]]
[[Category: Bargsten, K]]
[[Category: Yang, C.-P.H]]
[[Category: Band Horwitz, S]]
[[Category: Xiao, H]]
[[Category: Steinmetz, M.O]]
[[Category: Kapitein, L.C]]
[[Category: Hua, S]]
[[Category: Hua, S]]
[[Category: Custar, D.W]]
[[Category: Jiang, K]]
[[Category: Hilbert, M]]
[[Category: Kapitein, L C]]
[[Category: Katrukha, E.A]]
[[Category: Katrukha, E A]]
[[Category: Prota, A E]]
[[Category: Rodriguez-Garcia, R]]
[[Category: Rodriguez-Garcia, R]]
[[Category: Jiang, K]]
[[Category: Steinmetz, M O]]
[[Category: Doodhi, H]]
[[Category: Xiao, H]]
[[Category: Yang, C P.H]]
[[Category: Cell cycle]]
[[Category: Cytoskeleton]]
[[Category: Microtubule]]
[[Category: Tubulin fold]]
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