4cy4

The Cryo-Electron Microscopy Structure of the CorA channel from Methanocaldococcus jannaschii at 21.6 Angstrom in low magnesium.

spinqualitylabelsall models 4cy4, resolution 21.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4cy4 is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [CORA_METJA] Mediates influx of magnesium ions. Publication Abstract from PubMed CorA channels are responsible for the uptake of essential magnesium ions by bacteria. X-ray crystal structures have been resolved for two full-length CorA channels, each in a non-conducting state with magnesium ions bound to the protein: These structures reveal a homo-pentameric quaternary structure with approximate 5-fold rotational symmetry about a central pore axis. We report the structure of the detergent solubilized Methanocaldococcus jannaschii CorA channel determined by Cryo-Electron Microscopy and Single Particle Averaging, supported by Small Angle X-ray Scattering and X-ray crystallography. This structure also shows a pentameric channel but with a highly asymmetric domain structure. The asymmetry of the domains includes differential separations between the trans-membrane segments, which reflects mechanical coupling of the cytoplasmic domain to the trans-membrane domain. This structure therefore reveals an important aspect of the gating mechanism of CorA channels by providing an indication of how the absence of magnesium ions leads to major structural changes. The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.,Cleverley RM, Kean J, Shintre CA, Baldock C, Derrick JP, Ford RC, Prince SM Biochim Biophys Acta. 2015 Jun 4. pii: S0005-2736(15)00180-7. doi:, 10.1016/j.bbamem.2015.06.002. PMID:26051127 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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