Sandbox WWC6: Difference between revisions
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<scene name='69/696302/Alpha-hemolysin_polar_residues/1'> | <scene name='69/696302/Alpha-hemolysin_polar_residues/1'>Alpha-hemolysin residue polarity</scene> | ||
{{Template:ColorKey_Hydrophobic}} | {{Template:ColorKey_Hydrophobic}} | ||
{{Template:ColorKey_Polar}} | {{Template:ColorKey_Polar}} | ||
===Pore formation=== | ===Pore formation=== | ||
Pore formation of hemolysins is believed to be a conserved process across subtypes. <ref name ="nat"/> | Pore formation of hemolysins is believed to be a conserved process across subtypes. <ref name ="nat"/> | ||
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===Role in infection=== | ===Role in infection=== | ||
Hemolysin lysis of red blood cells is a marker for many kinds of pathogenic infection characterized by death of red blood cells. | Hemolysin lysis of red blood cells is a marker for many kinds of pathogenic infection characterized by death of red blood cells. <ref name="hem"/> | ||
===Oncology=== | ===Oncology=== | ||
Thermostable direct hemoslysin (TDH) is one type of hemolysin, secreted by ''Vibrio parahaemolyticus'', that may be linked to the down regulation of colon carcinoma cell proliferation. <ref>http://www.sciencedirect.com/science/article/pii/S030441651200116X<ref> | Thermostable direct hemoslysin (TDH) is one type of hemolysin, secreted by ''Vibrio parahaemolyticus'', that may be linked to the down regulation of colon carcinoma cell proliferation. The presence of this hemolysin is responsible for the influx of calcium ions from the extracellular space, activating protein kinase C, an inhibitor of tyrosine kinase activity on a key growth factor of this cancer.<ref>http://www.sciencedirect.com/science/article/pii/S030441651200116X<ref> | ||
===Hemolytic anemia=== | ===Hemolytic anemia=== | ||
Hemolytic anemia occurs when lysis of red blood cells occurs are rates faster than they can be replaced by bone marrow. <ref>https://www.nhlbi.nih.gov/health/health-topics/topics/ha<ref> | Hemolytic anemia occurs when lysis of red blood cells occurs are rates faster than they can be replaced by bone marrow. Hypoxia due to this condition can result in dizziness, shortness of breath, poor maintenance of body temperature, and jaundice. <ref>https://www.nhlbi.nih.gov/health/health-topics/topics/ha<ref> | ||
