Sandbox WWC9: Difference between revisions
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== Structure == | == Structure == | ||
Architecture | === Architecture === | ||
The µ-OR crystalized is that of the Mus musculus and has been given the protein database (PDB) identification 4DKL. This protein was crystalized on a 2.8 Å resolution with a bound irreversible morphinan antagonist β-funaltrexamine (β-FNA). The crystal structure of the protein shows the seven transmembrane helices characteristic of GPCRs that are connected by three extracellular loops and three intracellular loops. The receptors are arranges in dimers closely associated with transmembrane (TM) helices 5 and 6 (See image). The receptor also displays alternating aqueous and lipidic layers corresponding to transmembrane domains. (2) | The µ-OR crystalized is that of the Mus musculus and has been given the protein database (PDB) identification 4DKL. This protein was crystalized on a 2.8 Å resolution with a bound irreversible morphinan antagonist β-funaltrexamine (β-FNA). The crystal structure of the protein shows the seven transmembrane helices characteristic of GPCRs that are connected by three extracellular loops and three intracellular loops. The receptors are arranges in dimers closely associated with transmembrane (TM) helices 5 and 6 (See image). The receptor also displays alternating aqueous and lipidic layers corresponding to transmembrane domains. (2) | ||
Binding site: | Binding site: | ||
