1ido: Difference between revisions

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[[Image:1ido.gif|left|200px]]
[[Image:1ido.gif|left|200px]]


{{Structure
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|SITE= <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ido OCA], [http://www.ebi.ac.uk/pdbsum/1ido PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ido RCSB]</span>
}}


'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''
'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''
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[[Category: Lee, J O.]]
[[Category: Lee, J O.]]
[[Category: Liddington, R.]]
[[Category: Liddington, R.]]
[[Category: cell adhesion protein]]
[[Category: Cell adhesion protein]]
[[Category: cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: extracellular matrix]]
[[Category: Extracellular matrix]]
[[Category: glycoprotein]]
[[Category: Glycoprotein]]
[[Category: integrin]]
[[Category: Integrin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:53:04 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:18:18 2008''

Revision as of 16:53, 2 May 2008

File:1ido.gif

Template:STRUCTURE 1ido

I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND


Overview

We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.

About this Structure

1IDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070 Page seeded by OCA on Fri May 2 19:53:04 2008

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