5axc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5axc is ~~ON HOLD until Jul 24 2017~~

==Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5axc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AXC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AXC FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ARJ:(2S,3R,5R)-3-(6-AMINO-9H-PURIN-9-YL)-2-HYDROXY-5-(HYDROXYMETHYL)CYCLOPENTANONE'>ARJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5axa|5axa]], [[5axb|5axb]], [[5axd|5axd]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5axc OCA], [http://pdbe.org/5axc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5axc RCSB], [http://www.ebi.ac.uk/pdbsum/5axc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5axc ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SAHH_MOUSE SAHH_MOUSE]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

__TOC__

</StructureSection>

[[Category: Adenosylhomocysteinase]]

[[Category: Ishihara, M]]

[[Category: Kusakabe, Y]]

[[Category: Tanaka, N]]

[[Category: Hydrolase]]

[[Category: Hydrolase nucleoside complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5axc is ON HOLD  until Jul 24 2017
+==Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin==
+<StructureSection load='5axc' size='340' side='right' caption='[[5axc]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5axc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AXC FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARJ:(2S,3R,5R)-3-(6-AMINO-9H-PURIN-9-YL)-2-HYDROXY-5-(HYDROXYMETHYL)CYCLOPENTANONE'>ARJ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5axa|5axa]], [[5axb|5axb]], [[5axd|5axd]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteinase Adenosylhomocysteinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.1.1 3.3.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5axc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5axc OCA], [http://pdbe.org/5axc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5axc RCSB], [http://www.ebi.ac.uk/pdbsum/5axc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5axc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SAHH_MOUSE SAHH_MOUSE]] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
+__TOC__
+</StructureSection>
+[[Category: Adenosylhomocysteinase]]
+[[Category: Ishihara, M]]
+[[Category: Kusakabe, Y]]
+[[Category: Tanaka, N]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase nucleoside complex]]