5cf0: Difference between revisions
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==Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6== | |||
<StructureSection load='5cf0' size='340' side='right' caption='[[5cf0]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cf0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CF0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CF0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FJS:N-{3-[2,4-DIHYDROXY-5-(ISOQUINOLIN-4-YL)PHENYL]-4-(4-METHOXYPHENYL)-1,2-OXAZOL-5-YL}CYCLOPROPANECARBOXAMIDE'>FJS</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cf0 OCA], [http://pdbe.org/5cf0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cf0 RCSB], [http://www.ebi.ac.uk/pdbsum/5cf0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cf0 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: He, J H]] | |||
[[Category: Li, J]] | |||
[[Category: Shi, F]] | |||
[[Category: Xiong, B]] | |||
[[Category: Chaperone-chaperone inhibitor complex]] | |||
[[Category: Heat shock protein 90]] | |||
[[Category: Inhibitor]] | |||
[[Category: N-terminal domain]] | |||
Revision as of 11:42, 14 July 2016
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6
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